|
|
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one_4-phosphate <=> H+ + 6,7-dimethyl-8-(1'-D-ribityl)lumazine + phosphate + H2O
|
2.5.1.78
6,7-dimethyl-8-ribityllumazine synthase
2.5.1.9
riboflavin synthase
|
–
–
|
| |
BRENDA:
BR49183;
BS411397;
BS422660
KEGG:
R04457
MetaCyc:
LUMAZINESYN-RXN
SABIO-RK:
7642;
8561
|
|
|
|
D-ribulose_5-phosphate <=> H+ + formate + L-3,4-dihydroxybutan-2-one_4-phosphate
|
4.1.99.12
3,4-dihydroxy-2-butanone-4-phosphate synthase
|
–
|
| |
BRENDA:
BR48836
KEGG:
R07281
MetaCyc:
DIOHBUTANONEPSYN-RXN
SABIO-RK:
9052
|
|
|
|
GTP + H2O <=> H+ + 2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + phosphate
|
3.5.4.29
GTP cyclohydrolase IIa
|
–
|
| |
BRENDA:
BR47585
KEGG:
R07306
MetaCyc:
RXN-10055
|
|
|
|
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + NADP+ <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H+
|
1.1.1.193
5-amino-6-(5-phosphoribosylamino)uracil reductase
|
–
|
| |
BRENDA:
BR29246
KEGG:
R03458
MetaCyc:
RIBOFLAVINSYNREDUC-RXN
|
|
|
|
5-amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine + H2O <=> 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + phosphate
|
3.1.3.104
5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase
|
–
|
| |
BRENDA:
BR51773
KEGG:
R07280
MetaCyc:
RIBOPHOSPHAT-RXN
SABIO-RK:
8920
|
|
|
|
riboflavin + ATP <=> FMN + ADP + H+
|
2.7.1.161
CTP-dependent riboflavin kinase
2.7.1.26
riboflavin kinase
|
–
–
|
| |
BRENDA:
BR47765
KEGG:
R00549
MetaCyc:
RIBOFLAVINKIN-RXN
SABIO-RK:
277
|
|
|
|
reduced_riboflavin + NADP+ <=> H+ + riboflavin + NADPH
|
1.5.1.30
flavin reductase (NADPH)
1.5.1.38
FMN reductase (NADPH)
1.5.1.41
riboflavin reductase [NAD(P)H]
|
–
–
–
|
| |
BRENDA:
BR36901
KEGG:
R05707
MetaCyc:
NADPH-DEHYDROGENASE-FLAVIN-RXN;
RXN-12445
SABIO-RK:
1843
|
|
|
|
2,5-diamino-6-(1-D-ribitylamino)-4(3H)-pyrimidinone_5'-phosphate + NAD+ <=> 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + NADH + H+
|
1.1.1.302
2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
|
–
|
| |
BRENDA:
BR49150-a;
BS402325
KEGG:
R09375
MetaCyc:
RXN-10057
|
|
|
|
H+ + H2O + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate <=> 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH3
|
3.5.4.26
diaminohydroxyphosphoribosylaminopyrimidine deaminase
|
–
|
| |
BRENDA:
BR26118
KEGG:
R03459
MetaCyc:
RIBOFLAVINSYNDEAM-RXN
|
|
|
|
FMN + ATP + H+ <=> FAD + diphosphate
|
2.7.7.2
FAD synthase
|
–
|
| |
BRENDA:
BR47867
KEGG:
R00161
MetaCyc:
FADSYN-RXN
SABIO-RK:
390
|
|
|
|
riboflavin + CTP <=> H+ + FMN + CDP
|
2.7.1.161
CTP-dependent riboflavin kinase
|
–
|
| |
BRENDA:
BR48885
KEGG:
R08574
MetaCyc:
RXN-9296
SABIO-RK:
15496
|
|
|
|
FADH2 + NADP+ <=> FAD + NADPH + H+
|
1.14.13.7
phenol 2-monooxygenase (NADPH)
1.18.1.2
ferredoxin---NADP+ reductase
1.5.1.30
flavin reductase (NADPH)
1.5.1.36
flavin reductase (NADH)
1.5.1.38
FMN reductase (NADPH)
1.5.1.41
riboflavin reductase [NAD(P)H]
1.5.1.45
FAD reductase [NAD(P)H]
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BR50246
KEGG:
R09520
MetaCyc:
RXN-13750
SABIO-RK:
7292
|
|
|
|
2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O <=> H+ + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + formate
|
3.5.1.102
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
|
–
|
| |
BRENDA:
BR49204
KEGG:
R09374
MetaCyc:
RXN-10056
|
|
|
|
H2O + GTP <=> H+ + diphosphate + 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone_5'-phosphate + formate
|
3.5.4.25
GTP cyclohydrolase II
|
–
|
| |
BRENDA:
BR26117
KEGG:
R00425
MetaCyc:
GTP-CYCLOHYDRO-II-RXN
SABIO-RK:
880
|
|
